Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.

The Biochemical journal - 16 Jun 2017

Fliegert Ralf, Watt Joanna M, Schöbel Anja, Rozewitz Monika D, Moreau Christelle, Kirchberger Tanja, Thomas Mark P, Sick Wiebke, Araujo Andrea C, Harneit Angelika, Potter Barry V L, Guse Andreas H

Abstract excerpt

TRPM2 (transient receptor potential channel, subfamily melastatin, member 2) is a Ca2+-permeable non-selective cation channel activated by the binding of adenosine 5'-diphosphoribose (ADPR) to its cytoplasmic NUDT9H domain (NUDT9 homology domain). Activation of TRPM2 by ADPR downstream of oxidative stress has been implicated in the pathogenesis of many human diseases, rendering TRPM2 an attractive novel target...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Diphosphate Ribose
Share to Arginine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Signaling

Share to Ion Channel Gating

Share to Patch-Clamp Techniques

Share to Pyrophosphatases

Share to TRPM Cation Channels

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 28515263
DOI: 10.1042/BCJ20170091
PMCID: PMC5473349

Genes

TRPM2
NUDT9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.PMID 28515263Read ↗

Domain-Specific Agonist Binding Affinities Explain Structural and Functional Regulation of TRPM2Semantic proximity Read ↗

Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2.Semantic proximity Read ↗

Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9.Semantic proximity Read ↗

Selective profiling of N- and C-terminal nucleotide-binding sites in a TRPM2 channel.Semantic proximity Read ↗

Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels.Semantic proximity Read ↗

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain.Semantic proximity Read ↗

TRPM2: a potential drug target to retard oxidative stress.Semantic proximity Read ↗

Intracellular calcium activates TRPM2 and its alternative spliced isoforms.Semantic proximity Read ↗

ADP-ribosylation: An emerging direction for disease treatmentSemantic proximity Read ↗

ADP-ribosylation from molecular mechanisms to therapeutic implicationsSemantic proximity Read ↗

The essential inter-domain interaction between NUDT9H and channel domain of human TRPM2 is also accomplished in transSemantic proximity Read ↗

ADP-ribosylation signalling and human diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.