Article

An Effector Index to Predict Target Genes at GWAS Loci

2021-06-22

Abstract excerpt

<title>Abstract</title> <p>Drug development and biological discovery require effective strategies to map existing genetic associations to causal genes. To approach this problem, we selected 12 common diseases and quantitative traits for which highly powered genome-wide association studies (GWAS) were available. For each disease or trait, we systematically curated positive control gene sets from Mendelian forms of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a324a7db-0ac0-5c98-be8f-f979e3dd2244
DOI: 10.21203/rs.3.rs-629030/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An Effector Index to Predict Target Genes at GWAS LociDOI 10.21203/rs.3.rs-629030/v1Read

An effector index to predict target genes at GWAS loci.Semantic proximity Read

An Effector Index to Predict Causal Genes at GWAS LociSemantic proximity Read

Predicting ExWAS findings from GWAS data: a shorter path to causal genes.Semantic proximity Read

Realizing the promise of genome-wide association studies for effector gene prediction.Semantic proximity Read

Open Targets Genetics: An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated lociSemantic proximity Read

Integration of genetic evidence to identify approved drug targetsSemantic proximity Read

Caution when using network partners for target identification in drug discoverySemantic proximity Read

Prioritizing effector genes at trait-associated loci using multimodal evidence.Semantic proximity Read

Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation.Semantic proximity Read

An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci.Semantic proximity Read

Benchmarking genome-wide association study causal gene prioritization for drug discoverySemantic proximity Read

Enhancing genotype-phenotype association with optimized machine learning and biological enrichment methodsSemantic proximity Read