Article

Caution when using network partners for target identification in drug discovery

2024-08-09

Abstract excerpt

Identifying novel, high-yield drug targets is challenging and often results in a high failure rate. However, recent data indicates that leveraging human genetic evidence to identify and validate these targets significantly increases the likelihood of success in drug development. Two recent papers from Open Targets claimed that around half of FDA-approved drugs had targets with direct human genetic evidence. By exp...

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Literature Corpus work: 3b8301b0-07e3-5348-9e1f-3df134003079
DOI: 10.1101/2024.08.08.607024

Open publication

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