Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation.

PloS one - 1 Jan 2015

Croteau-Chonka Damien C, Rogers Angela J, Raj Towfique, McGeachie Michael J, Qiu Weiliang, Ziniti John P, Stubbs Benjamin J, Liang Liming, Martinez Fernando D, Strunk Robert C, Lemanske Robert F, Liu Andrew H, Stranger Barbara E, Carey Vincent J, Raby Benjamin A

Abstract excerpt

Disease-associated loci identified through genome-wide association studies (GWAS) frequently localize to non-coding sequence. We and others have demonstrated strong enrichment of such single nucleotide polymorphisms (SNPs) for expression quantitative trait loci (eQTLs), supporting an important role for regulatory genetic variation in complex disease pathogenesis. Herein we describe our initial efforts to develop...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Immune System Diseases

Share to Metabolic Diseases

Share to Models, Genetic

Share to Predictive Value of Tests

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 26474488
DOI: 10.1371/journal.pone.0140758
PMCID: PMC4608673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation.PMID 26474488Read ↗

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits.Semantic proximity Read ↗

Whole Genome DNA and RNA Sequencing of Whole Blood Elucidates the Genetic Architecture of Gene Expression Underlying a Wide Range of DiseasesSemantic proximity Read ↗

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.Semantic proximity Read ↗

Functional Characterization of Genetic Variant Effects on Expression.Semantic proximity Read ↗

Whole genome DNA and RNA sequencing of whole blood elucidates the genetic architecture of gene expression underlying a wide range of diseases.Semantic proximity Read ↗

Whole Genome DNA and RNA Sequencing of Whole Blood Elucidates the Genetic Architecture of Gene Expression Underlying a Wide Range of DiseasesSemantic proximity Read ↗

Leveraging functional annotation to identify genes associated with complex diseases.Semantic proximity Read ↗

Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies.Semantic proximity Read ↗

Large-scale East-Asian eQTL mapping reveals novel candidate genes for LD mapping and the genomic landscape of transcriptional effects of sequence variants.Semantic proximity Read ↗

Combining eQTL and SNP Annotation Data to Identify Functional Noncoding SNPs in GWAS Trait-Associated Regions.Semantic proximity Read ↗

Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes.Semantic proximity Read ↗

Predicting target genes of non-coding regulatory variants with IRT.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.