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Article

Prioritizing effector genes at trait-associated loci using multimodal evidence.

Nature genetics - 1 Feb 2025

Schipper Marijn, de Leeuw Christiaan A, Maciel Bernardo A P C, Wightman Douglas P, Hubers Nikki, Boomsma Dorret I, O'Donovan Michael C, Posthuma Danielle

Abstract excerpt

Genome-wide association studies (GWAS) yield large numbers of genetic loci associated with traits and diseases. Predicting the effector genes that mediate these locus-trait associations remains challenging. Here we present the FLAMES (fine-mapped locus assessment model of effector genes) framework, which predicts the most likely effector gene in a locus. FLAMES creates machine learning predictions from biological...

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PMID: 39930082
DOI: 10.1038/s41588-025-02084-7

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