Article

An Effector Index to Predict Causal Genes at GWAS Loci

2020-06-28

Abstract excerpt

Drug development and biological discovery require effective strategies to map existing genetic associations to causal genes. To approach this problem, we began by identifying a set of positive control genes for 12 common diseases and traits that cause a Mendelian form of the disease or are the target of a medicine used for disease treatment. We then identified a widely-available set of genomic features enriching G...

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Literature Corpus work: 30be0fb1-8d9a-5cfd-9f80-22d01ae91127
DOI: 10.1101/2020.06.28.171561

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