Article

Single-cell and spatial transcriptomics reveals the human liver immunological landscape and myeloid dysfunction in PSC

2023-08-01

Abstract excerpt

<h4>Background</h4> Primary sclerosing cholangitis (PSC) is an immune-mediated cholestatic liver disease characterized by bile retention, biliary tree destruction, and progressive fibrosis leading to end stage liver disease and transplantation. There is an unmet need to understand the cellular composition of the PSC liver and how it underlies disease pathogenesis. As such, we generated a comprehensive atlas of th...

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Literature Corpus work: edcdc974-ce72-5c3b-a325-2cb76e07f663
DOI: 10.1101/2023.07.28.550550

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