Article

Myeloid cells contribute to bystander CD8 T cell accumulation in metabolic-associated steatohepatitis and are sufficient for fibrosis

2025-12-19

Abstract excerpt

<h4>Background & Aims</h4> Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of liver fibrosis, morbidity, and mortality. It is characterized by the accumulation of fat in hepatocytes causing cell death followed by stromal cell activation and scar deposition at later disease stages. While a marked accumulation of cytotoxic CD8 T cells is observed in MASH in humans and mice, the role of ad...

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Literature Corpus work: 930c018b-2ed5-5583-b72e-c4e526d37293
DOI: 10.64898/2025.12.17.694415

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