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Article

Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implications

18 May 2022

Abstract excerpt

Objective The diversity of the tumour microenvironment (TME) of intrahepatic cholangiocarcinoma (iCCA) has not been comprehensively assessed. We aimed to generate a novel molecular iCCA classifier that incorporates elements of the stroma, tumour and immune microenvironment (‘STIM’ classification). Design We applied virtual deconvolution to transcriptomic data from ~900 iCCAs, enabling us to devise a novel...

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PMID: 35584893
DOI: 10.1136/gutjnl-2021-326514

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