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Spatial and Single-Cell Transcriptomics Decipher the Crosstalk Environment of <i>DEFB1</i> <sup>+</sup> Cancer Cells and <i>IFI30</i> <sup>+</sup> Macrophages in Intrahepatic Cholangiocarcinoma

2025-11-25

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is a rare but highly aggressive primary liver malignancy distinguished by a profoundly heterogeneous tumor microenvironment, which underlies its limited response to targeted and immune-based therapies. Deciphering the cellular composition and intercellular signaling within this complex ecosystem is critical to understanding ICC progression and to identifying actionable therape...

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Literature Corpus work
db1a0406-a136-5b64-b5bf-5e7e93c1f42f
DOI
10.1101/2025.11.22.689892
Open publication

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Spatial and Single-Cell Transcriptomics Decipher the Crosstalk Environment of <i>DEFB1</i> <sup>+</sup> Cancer Cells and <i>IFI30</i> <sup>+</sup> Macrophages in Intrahepatic CholangiocarcinomaDOI 10.1101/2025.11.22.689892
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