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The Role of Endoplasmic Reticulum Stress in Human Pathology

11 Nov 2014

Abstract excerpt

Numerous genetic and environmental insults impede the ability of cells to properly fold and posttranslationally modify secretory and transmembrane proteins in the endoplasmic reticulum (ER), leading to a buildup of misfolded proteins in this organelle--a condition called ER stress. ER-stressed cells must rapidly restore protein-folding capacity to match protein-folding demand if they are to survive. In the...

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PMID: 25387057
DOI: 10.1146/annurev-pathol-012513-104649

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