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Article

Cisd2 slows down liver aging and attenuates age‐related metabolic dysfunction in male mice

22 Nov 2021

Abstract excerpt

The liver plays a pivotal role in mammalian aging. However, the mechanisms underlying liver aging remain unclear. Cisd2 is a pro-longevity gene in mice. Cisd2 mediates lifespan and healthspan via regulation of calcium homeostasis and mitochondrial functioning. Intriguingly, the protein level of Cisd2 is significantly decreased by about 50% in the livers of old male mice. This down-regulation of Cisd2 may result...

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PMID: 34811857
DOI: 10.1111/acel.13523

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