Back to search

Article

Establishment of CD1b-restricted immunity to lipid antigens in the pulmonary response to <i>Mycobacterium tuberculosis</i> infection

2023-05-24

Abstract excerpt

CD1 is an antigen presenting glycoprotein homologous to MHC I; however, CD1 proteins present lipid rather than peptide antigen. CD1 proteins are well established to present lipid antigens of Mycobacterium tuberculosis (Mtb) to T cells, but understanding the role of CD1-restricted immunity in vivo in response to Mtb infection has been limited by availability of animal models naturally expressing the CD1 proteins...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a2ef0a8f-9e80-5785-a249-4c2ffd242fa5
DOI
10.1101/2023.05.23.541963
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Establishment of CD1b-restricted immunity to lipid antigens in the pulmonary response to <i>Mycobacterium tuberculosis</i> infectionDOI 10.1101/2023.05.23.541963
CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice.Semantic proximity
Mycolic acid-specific T cells protect against Mycobacterium tuberculosis infection in a humanized transgenic mouse modelSemantic proximity
Human CD1c-autoreactive T-cells recognise <i>Mycobacterium tuberculosis</i> –infected antigen-presenting cells and display cytotoxic effector programmesSemantic proximity
A conserved human T cell population targets mycobacterial antigens presented by CD1bSemantic proximity
T-Cell Responses to CD1-Presented Lipid Antigens in Humans with <i>Mycobacterium tuberculosis</i> InfectionSemantic proximity
B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and putative functional rolesSemantic proximity
B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles.Semantic proximity
Unbiased definition of a shared T-cell receptor motif enables population-based studies of tuberculosisSemantic proximity
Individuals with latent tuberculosis infection display pulmonary airway enrichment and recall recruitment of CD4+ TRM with protective functional phenotypes.Semantic proximity
<i>Mycobacterium tuberculosis</i> ‐specific CD8 <sup>+</sup> T cells are functionally and phenotypically different between latent infection and active diseaseSemantic proximity
Latent <i>Mycobacterium tuberculosis</i> infection provides protection for the host by changing the activation state of the innate immune systemSemantic proximity
Characterization of B-1b cells as antigen presenting cells in the immune response to gp43 from Paracoccidioides brasiliensis in vitro.Semantic proximity
Select a neighboring publication to make it the new centre.