Article

A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

2019-09-24

Abstract excerpt

The ClpXP degradation machine consists of a hexameric AAA+ unfoldase (ClpX) and a pair of heptameric serine protease rings (ClpP) that unfold, translocate, and subsequently degrade client proteins. ClpXP is an important target for drug development against infectious diseases. Although structures are available for isolated ClpX and ClpP rings, it remains unknown how symmetry mismatched ClpX and ClpP work in tandem...

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Literature Corpus work: f55d82a8-be48-5388-bb3b-08af772fddf4
DOI: 10.1101/780494

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