Article

Human mitochondrial Lon protease initiates unidirectional degradation from either substrate terminus

2026-05-20

Abstract excerpt

The ATP-dependent Lon protease (LonP1) unfolds and progressively degrades damaged or redundant proteins in the mitochondrial matrix. However, how LonP1 recognizes substrates remains unclear. Here, we investigated LonP1 degradation of the mitochondrial transcription factor TFAM, a physiological substrate. Using engineered TFAM variants carrying bulky moieties at either terminus, we show that degradation can initiat...

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Literature Corpus work: 50f8f6f0-6a1a-53ed-a134-c07d463f16e6
DOI: 10.64898/2026.05.18.725877

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