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Article

CEBPA double-mutated acute myeloid leukaemia harbours concomitant molecular mutations in 76·8% of cases with TET2 and GATA2 alterations impacting prognosis.

British journal of haematology - 1 Jun 2013

Grossmann Vera, Haferlach Claudia, Nadarajah Niroshan, Fasan Annette, Weissmann Sandra, Roller Andreas, Eder Christiane, Stopp Elisa, Kern Wolfgang, Haferlach Torsten, Kohlmann Alexander, Schnittger Susanne

Abstract excerpt

Acute myeloid leukaemia (AML) with CEBPA mutations is listed as a provisional entity in the current World Health Organization classification. A difference in clinical outcome between single- (sm) and double-mutated (dm) cases has been reported, whereupon CEBPAdm cases were shown to be associated with better overall survival (OS). The occurrence and prognostic impact of concomitant molecular mutations in addition...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23521373
DOI: 10.1111/bjh.12297

Genes

GATA2
TET2
FLT3
ASXL1
IDH1
KRAS
NPM1
NRAS
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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