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Article

Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML.

Blood - 15 Jul 2021

Mulet-Lazaro Roger, van Herk Stanley, Erpelinck Claudia, Bindels Eric, Sanders Mathijs A, Vermeulen Carlo, Renkens Ivo, Valk Peter, Melnick Ari M, de Ridder Jeroen, Rehli Michael, Gebhard Claudia, Delwel Ruud, Wouters Bas J

Abstract excerpt

Transcriptional deregulation is a central event in the development of acute myeloid leukemia (AML). To identify potential disturbances in gene regulation, we conducted an unbiased screen of allele-specific expression (ASE) in 209 AML cases. The gene encoding GATA binding protein 2 (GATA2) displayed ASE more often than any other myeloid- or cancer-related gene. GATA2 ASE was strongly associated with CEBPA double...

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Share to CCAAT-Enhancer-Binding Proteins
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Epigenesis, Genetic

Share to GATA2 Transcription Factor

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Remission Induction

Source

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Identifiers

PMID: 33831168
DOI: 10.1182/blood.2020009244
PMCID: PMC8489178

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