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Inhibitory synaptic transmission is impaired at higher extracellular Ca <sup>2+</sup> concentrations in <i>Scn1a</i> <sup>+/−</sup> mouse model of Dravet syndrome

2021-02-04

Abstract excerpt

<h4>ABSTRACT</h4> Dravet syndrome (DS) is an intractable form of childhood epilepsy that occurs in infancy. More than 80% of all patients have a heterozygous abnormality in the SCN1A gene, which encodes a subunit of Na + channels in the brain. However, the detailed pathogenesis of DS remains unclear. This study investigated the synaptic pathogenesis of this disease in terms of excitatory/inhibitory balance usin...

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Literature Corpus work
80ede60e-2c31-5492-bf7f-69fde3eecde9
DOI
10.1101/2021.02.04.429687
Open publication

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Inhibitory synaptic transmission is impaired at higher extracellular Ca <sup>2+</sup> concentrations in <i>Scn1a</i> <sup>+/−</sup> mouse model of Dravet syndromeDOI 10.1101/2021.02.04.429687
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