Article

Investigations of human myosin VI targeting using optogenetically-controlled cargo loading

2016-08-11

Abstract excerpt

Myosins play countless critical roles in the cell, each requiring it to be activated at a specific location and time. To control myosin VI with this specificity, we created a novel optogenetic tool for activating myosin VI by fusing the light-sensitive Avena sativa phototropin1 LOV2 domain to a peptide from Dab2 (LOVDab), a myosin VI cargo protein. Our approach harnesses the native targeting and activation mechan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9bbd8e4e-dec5-52ba-a65a-6467d16c166a
DOI: 10.1101/068965

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigations of human myosin VI targeting using optogenetically-controlled cargo loadingDOI 10.1101/068965Read

Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells.Semantic proximity Read

Myosins: Tails (and Heads) of Functional DiversitySemantic proximity Read

Unconventional myosins in cell movement, membrane traffic, and signal transduction.Semantic proximity Read

The myosin superfamily at a glanceSemantic proximity Read

Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic.Semantic proximity Read

More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va.Semantic proximity Read

TULIPs: tunable, light-controlled interacting protein tags for cell biology.Semantic proximity Read

Optogenetic Signaling Activation in Zebrafish EmbryosSemantic proximity Read

Myosin VI has a one track mind versus myosin Va when moving on actin bundles or at an intersection.Semantic proximity Read

Myosin structure and function.Semantic proximity Read

An optogenetic toolkit for robust activation of FGF, BMP, & Nodal signaling in zebrafishSemantic proximity Read

Identification of an organelle receptor for myosin-Va.Semantic proximity Read