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Article

AMPK is mitochondrial medicine for neuromuscular disorders

19 Apr 2023

Abstract excerpt

Duchenne muscular dystrophy (DMD), myotonic dystrophy type 1 (DM1), and spinal muscular atrophy (SMA) are the most prevalent neuromuscular disorders (NMDs) in children and adults. Central to a healthy neuromuscular system are the processes that govern mitochondrial turnover and dynamics, which are regulated by AMP-activated protein kinase (AMPK). Here, we survey mitochondrial stresses that are common between, as...

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PMID: 37080889
DOI: 10.1016/j.molmed.2023.03.008

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