Article

PGC-1α regulates mitochondrial calcium homeostasis, SR stress and cell death to mitigate skeletal muscle aging

2018-10-23

Abstract excerpt

Age-related impairment of muscle function severely affects the health of an increasing elderly population. While causality and the underlying mechanisms remain poorly understood, exercise is an efficient intervention to blunt these aging effects. We thus investigated the role of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a potent regulator of mitochondrial function and exercise adapt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2422a5b-43cb-554b-9602-0d931760540a
DOI: 10.1101/451229

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PGC-1α regulates mitochondrial calcium homeostasis, SR stress and cell death to mitigate skeletal muscle agingDOI 10.1101/451229Read

The role of PGC‐1 coactivators in aging skeletal muscle and heartSemantic proximity Read

Mitochondria and PGC-1α in Aging and Age-Associated DiseasesSemantic proximity Read

Mitochondrial Metabolic Reprogramming Induced by Calorie RestrictionSemantic proximity Read

Aging, senescence and mitochondria: the PGC-1/ERR axisSemantic proximity Read

PGC-1α-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart FailureSemantic proximity Read

Regulation of skeletal muscle mitochondrial function: genes to proteinsSemantic proximity Read

Regulation of mitochondrial biogenesisSemantic proximity Read

PGC-1 coactivators: inducible regulators of energy metabolism in health and diseaseSemantic proximity Read

Fine-Tuning of PGC1α Expression Regulates Cardiac Function and LongevitySemantic proximity Read

Mechanisms of Exercise‐Induced Mitochondrial Biogenesis in Skeletal Muscle: Implications for Health and DiseaseSemantic proximity Read

Lipid mediated ER-stress contributes to the pathogenesis of mitochondrial myopathiesSemantic proximity Read

Complex Coordination of Cell Plasticity by a PGC-1α-controlled Transcriptional Network in Skeletal MuscleSemantic proximity Read