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Mitochondrial Metabolic Reprogramming Induced by Calorie Restriction

19 Aug 2012

Abstract excerpt

SIGNIFICANCE: Calorie restriction (CR) is a known intervention that delays most aging processes. Most of the beneficial effects of CR are mediated by improved maintenance of mitochondrial performance in aged individuals. The control of mitochondrial biogenesis, apoptosis, and protein turnover is required for healthy aging. CR is able to induce molecular mechanisms that preserve oxidative capacity and decrease...

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PMID: 22901095
DOI: 10.1089/ars.2012.4866

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