Article

Lipid mediated ER-stress contributes to the pathogenesis of mitochondrial myopathies

2026-06-12

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial diseases are a heterogeneous group of genetic disorders caused by impaired oxidative phosphorylation (OxPhos). When skeletal muscle is predominantly affected, they are defined as primary mitochondrial myopathies. Although the genetic causes of mitochondrial myopathies and the resulting bioenergetic impairments are well established, the metabolic drivers behind progressive muscle dy...

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Literature Corpus work: e62b54c9-df11-55c2-a0f6-4d4238daced9
DOI: 10.64898/2026.06.10.731336

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