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The role of PGC‐1 coactivators in aging skeletal muscle and heart

25 Jan 2012

Abstract excerpt

Aging is the progressive decline in cellular, tissue, and organ function. This complex process often manifests as loss of muscular strength, cardiovascular function, and cognitive ability. Mitochondrial dysfunction and decreased mitochondrial biogenesis are believed to participate in metabolic abnormalities and loss of organ function, which will eventually contribute to aging and decreased lifespan. In this...

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PMID: 22279035
DOI: 10.1002/iub.608

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