Article

Collateral Sensitivity Strongly Connected Components in Real-World Clinical Surveillance Data Are Confounded by Clonal Lineage

2026-08-10

Abstract excerpt

Collateral sensitivity (CS) — acquisition of resistance to one antibiotic inducing hyper-sensitivity to another — offers an evolutionary trap for multidrug-resistant pathogens. A strongly connected component (SCC) in the directed CS graph represents a closed cycle in which every drug is reachable from every other via successive CS edges. Prior evidence for CS SCCs derives from in vitro experiments; whether such s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a22f1c1c-ba92-51d3-adf7-7ba40246cc54
DOI: 10.64898/2026.08.07.743632

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Collateral Sensitivity Strongly Connected Components in Real-World Clinical Surveillance Data Are Confounded by Clonal LineageDOI 10.64898/2026.08.07.743632Read

Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli.Semantic proximity Read

Use of collateral sensitivity networks to design drug cycling protocols that avoid resistance development.Semantic proximity Read

Conserved collateral susceptibility networks in diverse clinical strains of <i>Escherichia coli</i>Semantic proximity Read

Dynamic genomic constraints reveal fitness trade-offs underlying bacterial resistance evolutionSemantic proximity Read

Divergent spontaneous antibiotic-resistance evolution confers reciprocal and exploitable collateral sensitivity effectsSemantic proximity Read

Phenotypical resistance correlation networks for 10 non-typhoidal Salmonella subpopulations in an active antimicrobial surveillance programme.Semantic proximity Read

Evolutionary instability of collateral susceptibility networks in ciprofloxacin resistant clinical <i>Escherichia coli</i> strainsSemantic proximity Read

Collateral Responses to Classical Cytotoxic Chemotherapies are Heterogeneous and Sensitivities are SparseSemantic proximity Read

Clustering large-scale biomedical data to model dynamic accumulation processes in disease progression and anti-microbial resistance evolutionSemantic proximity Read

Assessment of Phenotype Microarray plates for rapid and high-throughput analysis of collateral sensitivity networksSemantic proximity Read

Evaluation of β-lactamase production and efflux pump overexpression in clinical isolates of Klebsiella pneumoniae and computational-network based hub genes identification.Semantic proximity Read

Assessment of Phenotype Microarray plates for rapid and high-throughput analysis of collateral sensitivity networks.Semantic proximity Read