Evaluation of β-lactamase production and efflux pump overexpression in clinical isolates of Klebsiella pneumoniae and computational-network based hub genes identification.

Abstract excerpt

AIM: This study aims to investigate the molecular mechanisms of multidrug resistance, especially β-lactamase and efflux pump-mediated resistance in clinical isolates of Klebsiella pneumoniae, and to analyze resistance genes using computational network for the identification of hub genes. METHODS: The clinical isolates of K. pneumoniae were screened for phenotypic detection of β-lactamase production and efflux...

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