Article

Genome-Wide in silico analysis reveals activation of a silent resistome driving imipenem resistance in Pseudomonas aeruginosa

2026-01-27

Abstract excerpt

Resistance to imipenem in Pseudomonas aeruginosa relies on multiple factors that remain poorly understood. In our work, we performed a systemic analysis of genome-wide changes involved in resistance in a set of 95 clinically unrelated strains, including 41 resistant (MIC ≥ 64 mg/L) and 54 susceptible (MIC ≤ 2 mg/L) isolates. Our approach is based on the pan-genomics analysis, combining the use of core-genome phylo...

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Literature Corpus work: 959c96ff-8361-5167-a8ff-b7664245ce78
DOI: 10.64898/2026.01.25.701575

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