Article

Dynamic genomic constraints reveal fitness trade-offs underlying bacterial resistance evolution

2025-08-21

Abstract excerpt

<h4>ABSTRACT</h4> Antimicrobial resistance (AMR) is often modelled as the accumulation of resistance genes leading to multidrug resistance (MDR). We show that gene co-occurrence patterns in two opportunistic pathogens are consistent with fitness trade-offs that constrain which combinations of resistance mechanisms coexist. We applied a combined pangenomic and machine-learning analysis to 9,584 Escherichia coli ge...

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Literature Corpus work: 500252f1-5382-5909-81f6-bc32c2901ad3
DOI: 10.1101/2025.08.20.671315

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