Article

Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing

2024-03-08

Abstract excerpt

Natural killer (NK) cells’ unique ability to kill transformed cells expressing stress ligands or lacking major histocompatibility complexes (MHC) has prompted their development for immunotherapy. However, NK cells have demonstrated only moderate responses against cancer in clinical trials and likely require advanced genome engineering to reach their full potential as a cancer therapeutic. Multiplex genome editing...

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Literature Corpus work: a22ea742-ba84-53df-ad8c-0ce5be33a495
DOI: 10.1101/2024.03.05.582637

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