Article

Virus-free CRISPR knock-in of a chimeric antigen receptor into <i>KLRC1</i> generates potent GD2-specific natural killer cells

2024-02-14

Abstract excerpt

Natural killer (NK) cells are an appealing off-the-shelf, allogeneic cellular therapy due to their cytotoxic profile. However, their activity against solid tumors remains suboptimal in part due to the upregulation of NK-inhibitory ligands, such as HLA-E, within the tumor microenvironment. Here, we utilize CRISPR-Cas9 to disrupt the KLRC1 gene (encoding the HLA-E-binding NKG2A receptor) and perform non-viral inser...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 858bf7f3-73d7-58ec-8540-3ab01e3a813a
DOI: 10.1101/2024.02.14.580371

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Virus-free CRISPR knock-in of a chimeric antigen receptor into <i>KLRC1</i> generates potent GD2-specific natural killer cellsDOI 10.1101/2024.02.14.580371Read

Enhanced NK-92 Cytotoxicity by CRISPR Genome Engineering Using Cas9 RibonucleoproteinsSemantic proximity Read

A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer ImmunotherapySemantic proximity Read

Gene-edited and CAR-NK cells: Opportunities and challenges with engineering of NK cells for immunotherapySemantic proximity Read

CRISPR/Cas9 edited tumor-associated immune cells in cancer immunotherapySemantic proximity Read

CRISPR, CAR-T, and NK: Current applications and future perspectivesSemantic proximity Read

Perturbomics of tumor-infiltrating NK cellsSemantic proximity Read

Site-specific genome engineering of primary human natural killer cells for programmable anti-tumor functionSemantic proximity Read

CRISPR Gene Editing of Human Primary NK and T Cells for Cancer ImmunotherapySemantic proximity Read

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapySemantic proximity Read

Exploiting the CRISPR‐Cas9 gene‐editing system for human cancers and immunotherapySemantic proximity Read

Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potencySemantic proximity Read

A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer ImmunotherapySemantic proximity Read