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Precision enhancement of CAR-NK cells through non-viral engineering and highly multiplexed base editing

1 May 2025

Abstract excerpt

BACKGROUND: Natural killer (NK) cells' unique ability to kill transformed cells expressing stress ligands or lacking major histocompatibility complexes (MHC) has prompted their development for immunotherapy. However, NK cells have demonstrated only moderate responses against cancer in clinical trials. METHODS: Advanced genome engineering may thus be used to unlock their full potential. Multiplex genome editing...

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PMID: 40341025
DOI: 10.1136/jitc-2024-009560

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