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Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors

19 Nov 2019

Abstract excerpt

The fusion of genome engineering and adoptive cellular therapy holds immense promise for the treatment of genetic disease and cancer. Multiplex genome engineering using targeted nucleases can be used to increase the efficacy and broaden the application of such therapies but carries safety risks associated with unintended genomic alterations and genotoxicity. Here, we apply base editor technology for multiplex...

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PMID: 31745080
DOI: 10.1038/s41467-019-13007-6

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