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Development of a Gene Editing Platform to Enhance CAR-T Therapy Through Inducible IL-15 Expression at the PD-1 Locus

2025-07-23

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Adoptive cell therapy (ACT) with genetically engineered T cells expressing chimeric antigen receptors (CARs) has emerged as a promising treatment option for patients with refractory leukaemia or lymphoma. Despite its success in type B malignancies, CAR-T cell therapy still faces some challenges such as toxicity, functional suppression by the tumour microenviro...

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Literature Corpus work
58ae2389-4008-5e32-b827-36531ed1840a
DOI
10.21203/rs.3.rs-7012598/v1
Open publication

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Development of a Gene Editing Platform to Enhance CAR-T Therapy Through Inducible IL-15 Expression at the PD-1 LocusDOI 10.21203/rs.3.rs-7012598/v1
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