Article
Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.
Science (New York, N.Y.) - 12 Dec 2014
Mansour Marc R, Abraham Brian J, Anders Lars, Berezovskaya Alla, Gutierrez Alejandro, Durbin Adam D, Etchin Julia, Lawton Lee, Sallan Stephen E, Silverman Lewis B, Loh Mignon L, Hunger Stephen P, Sanda Takaomi, Young Richard A, Look A Thomas
Abstract excerpt
In certain human cancers, the expression of critical oncogenes is driven from large regulatory elements, called super-enhancers, that recruit much of the cell's transcriptional apparatus and are defined by extensive acetylation of histone H3 lysine 27 (H3K27ac). In a subset of T-cell acute lymphoblastic leukemia (T-ALL) cases, we found that heterozygous somatic mutations are acquired that introduce binding motifs...
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