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Article

A polygenic score method boosted by non-additive models.

Nature communications - 29 May 2024

Ohta Rikifumi, Tanigawa Yosuke, Suzuki Yuta, Kellis Manolis, Morishita Shinichi

Abstract excerpt

Dominance heritability in complex traits has received increasing recognition. However, most polygenic score (PGS) approaches do not incorporate non-additive effects. Here, we present GenoBoost, a flexible PGS modeling framework capable of considering both additive and non-additive effects, specifically focusing on genetic dominance. Building on statistical boosting theory, we derive provably optimal GenoBoost...

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Source

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Identifiers

PMID: 38811555
DOI: 10.1038/s41467-024-48654-x
PMCID: PMC11522481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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