Article

LINE-1 Depletion at Promoters of Neurodevelopmental Disorder Genes: A Genome-Wide Analysis

2026-04-10

Abstract excerpt

LINE-1 retrotransposons constitute approximately 17% of the human genome and are capable of influencing gene expression when inserted in proximity to regulatory regions. Neurodevelopmental disorder (NDD) genes require precise spatiotemporal regulation during brain development; however, the relationship between LINE-1 occupancy and the promoter architecture of NDD-associated loci has not been systematically examine...

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Literature Corpus work: a21c0118-6bc2-516b-80d1-8275a5f59370
DOI: 10.20944/preprints202604.0715.v1

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