Article

Genetic control of KRAB-ZFP genes explains distal CpG-site methylation which associates with human disease phenotypes

2022-01-20

Abstract excerpt

Krüppel-associated box zinc finger proteins (KRAB-ZFPs) are the largest gene family of transcriptional regulators in higher vertebrates. We have developed a method for inferring these factors’ DNA binding-sites in vivo . We achieved this by combining the genome-wide association of methylation at 573,027 CpG-sites (meQTL) in blood and KRAB-ZFP RNA expression changes (eQTL). This method’s efficacy is clearly demons...

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Identifiers and source

Literature Corpus work: 4c328491-c949-5527-8bac-314eb7fd529f
DOI: 10.1101/2022.01.18.476742

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