Article
KAP1 regulates gene networks controlling T-cell development and responsiveness.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2012
Santoni de Sio Francesca R, Barde Isabelle, Offner Sandra, Kapopoulou Adamandia, Corsinotti Andrea, Bojkowska Karolina, Genolet Raphaël, Thomas James H, Luescher Immanuel F, Pinschewer Daniel, Harris Nicola, Trono Didier
Abstract excerpt
Chromatin remodeling at specific genomic loci controls lymphoid differentiation. Here, we investigated the role played in this process by Kruppel-associated box (KRAB)-associated protein 1 (KAP1), the universal cofactor of KRAB-zinc finger proteins (ZFPs), a tetrapod-restricted family of transcriptional repressors. T-cell-specific Kap1-deleted mice displayed a significant expansion of immature thymocytes,...
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