Article

Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction

2024-08-01

Abstract excerpt

<title>Abstract</title> <p>Aging of the brain vasculature plays a key role in the development of neurovascular and neurodegenerative diseases, thereby contributing to cognitive impairment. Among other factors, DNA damage strongly promotes cellular aging, however, the role of genomic instability in brain endothelial cells (EC) and its potential effect on brain homeostasis is still largely unclear. We here investig...

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Literature Corpus work: a208877c-adb6-51da-a8b2-59d20ef6b748
DOI: 10.21203/rs.3.rs-4358616/v1

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