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Article

Genomic instability and vascular aging: a focus on nucleotide excision repair.

Trends in cardiovascular medicine - 1 Feb 2014

Wu Haiyan, Roks Anton J M

Abstract excerpt

Genomic instability is recognized as one of the primary mechanisms that lead to organismal aging. When genomic maintenance systems, such as nucleotide excision repair, are defective, genomic instability is promoted, which causes accelerated aging (progeria). This can be observed in humans as well as in mouse models of progeroid syndromes. The role of genomic instability related to nuclear DNA is currently under...

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PMID: 23953979
DOI: 10.1016/j.tcm.2013.06.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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