Article
Nucleotide excision DNA repair is associated with age-related vascular dysfunction.
Circulation - 24 Jul 2012
Durik Matej, Kavousi Maryam, van der Pluijm Ingrid, Isaacs Aaron, Cheng Caroline, Verdonk Koen, Loot Annemarieke E, Oeseburg Hisko, Bhaggoe Usha Musterd, Leijten Frank, van Veghel Richard, de Vries René, Rudez Goran, Brandt Renata, Ridwan Yanto R, van Deel Elza D, de Boer Martine, Tempel Dennie, Fleming Ingrid, Mitchell Gary F, Verwoert Germaine C, Tarasov Kirill V, Uitterlinden Andre G, Hofman Albert, Duckers Henricus J, van Duijn Cornelia M, Oostra Ben A, Witteman Jacqueline C M, Duncker Dirk J, Danser A H Jan, Hoeijmakers Jan H, Roks Anton J M
Abstract excerpt
BACKGROUND: Vascular dysfunction in atherosclerosis and diabetes mellitus, as observed in the aging population of developed societies, is associated with vascular DNA damage and cell senescence. We hypothesized that cumulative DNA damage during aging contributes to vascular dysfunction. METHODS AND RESULTS: In mice with genomic instability resulting from the defective nucleotide excision repair genes ERCC1 and...
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