DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to A lzheimer's neuropathology progression: a population‐based study in the M edical R esearch C ouncil C ognitive F unction and A geing S tudy ( MRC ‐ CFAS ) cohort

Abstract excerpt

AIMS: Abnormalities of the brain microvasculature in Alzheimer's disease have led to the vascular hypothesis of the disease, which predicts that vascular changes precede neuronal dysfunction and degeneration. To determine the spectrum of endothelial injury in the elderly and its relation to Alzheimer-type neuropathology we investigated DNA damage in a population-based sample derived from the Medical Research...

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