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Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response.

Aging cell - 1 May 2024

van der Linden Janette, Stefens Sanne J M, Heredia-Genestar José María, Ridwan Yanto, Brandt Renata M C, van Vliet Nicole, de Beer Isa, van Thiel Bibi S, Steen Herman, Cheng Caroline, Roks Anton J M, Danser A H Jan, Essers Jeroen, van der Pluijm Ingrid

Abstract excerpt

Cardiovascular diseases are the number one cause of death globally. The most important determinant of cardiovascular health is a person's age. Aging results in structural changes and functional decline of the cardiovascular system. DNA damage is an important contributor to the aging process, and mice with a DNA repair defect caused by Ercc1 deficiency display hypertension, vascular stiffening, and loss of...

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PMID: 38451018
DOI: 10.1111/acel.14126
PMCID: PMC11113264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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