Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.

Aging cell - 1 Mar 2020

Kim Dong Eun, Dollé Martijn E T, Vermeij Wilbert P, Gyenis Akos, Vogel Katharina, Hoeijmakers Jan H J, Wiley Christopher D, Davalos Albert R, Hasty Paul, Desprez Pierre-Yves, Campisi Judith

Abstract excerpt

ERCC1 (excision repair cross complementing-group 1) is a mammalian endonuclease that incises the damaged strand of DNA during nucleotide excision repair and interstrand cross-link repair. Ercc1-/Δ mice, carrying one null and one hypomorphic Ercc1 allele, have been widely used to study aging due to accelerated aging phenotypes in numerous organs and their shortened lifespan. Ercc1-/Δ mice display combined features...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to Endonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Gene Knockdown Techniques

Share to Stem Cells

Share to Tumor Necrosis Factor-alpha

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 31737985
DOI: 10.1111/acel.13072
PMCID: PMC7059167

Genes

ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.PMID 31737985Read ↗

Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice.Semantic proximity Read ↗

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cellsSemantic proximity Read ↗

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and agingSemantic proximity Read ↗

Age-related motor neuron degeneration in DNA repair-deficient Ercc1 miceSemantic proximity Read ↗

A Mouse Model of Accelerated Liver Aging Caused by a Defect in DNA RepairSemantic proximity Read ↗

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of miceSemantic proximity Read ↗

Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair.Semantic proximity Read ↗

Identification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stressSemantic proximity Read ↗

Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response.Semantic proximity Read ↗

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence.Semantic proximity Read ↗

Cells from ERCC1-deficient mice show increased genome instability and a reduced frequency of S-phase-dependent illegitimate chromosome exchange but a normal frequency of homologous recombination.Semantic proximity Read ↗

Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.