USP7 aggravates diabetic cardiomyopathy by stabilizing Keap1 to govern cardiac oxidative stress and pyroptosis

Abstract excerpt

<title>Abstract</title> <p>Background Diabetic cardiomyopathy (DCM) represents one of the most severe cardiac complications arising from diabetes. However, there is a lack of specific treatment strategies for DCM in clinic. As a key deubiquitylation protease, ubiquitin-specific protease 7 (USP7) has been proved to aggravate pathological processes in a variety of cardiovascular diseases. Despite extensive investig...

Topics

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• Autophagy in Disease and Therapy
• Cardiomyopathy and Myosin Studies
• Cardiovascular Function and Risk Factors
• Endoplasmic Reticulum Stress and Disease
• Metabolism, Diabetes, and Cancer
• Parkinson's Disease Mechanisms and Treatments
• Signaling Pathways in Disease
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

a3e6c9c7-2928-5676-8f7f-cbad9810033f

DOI

10.21203/rs.3.rs-7334691/v1