Article

Gut microbiota DPP4-like enzymes are increased in type-2 diabetes and contribute to incretin inactivation

2023-12-18

Abstract excerpt

<h4>Background: </h4> The gut microbiota controls broad aspects of human metabolism and feeding behavior, but the basis for this control remains largely unclear. Given the key role of human dipeptidyl peptidase 4 (DPP4) in host metabolism, we investigate whether microbiota DPP4-like counterparts perform the same function. <h4>Results:</h4> We identify novel functional homologs of human DPP4 in several bacterial sp...

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Literature Corpus work: b2f618f3-af8c-5bc8-a45e-087af3a84821
DOI: 10.1101/2023.12.18.572132

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