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Article

Polymorphic metabolism by functional alterations of human cytochrome P450 enzymes.

Archives of pharmacal research - 1 Nov 2011

Lee Im-Soon, Kim Donghak

Abstract excerpt

The study of cytochrome P450 pharmacogenomics is of particular interest because of its promise in the development of rational means to optimize drug therapy with respect to patient's genotype to ensure maximum efficacy with minimal adverse effects. Drug metabolizing P450 enzymes are polymorphic and are the main phase I enzymes responsible for the metabolism of clinical drugs. Therefore, polymorphisms in the P450s...

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Identifiers

PMID: 22139682
DOI: 10.1007/s12272-011-1103-2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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