Back to search

Article

Sodium valproate rescues expression of <i>TRANK1</i> in iPSC-derived neural cells that carry a genetic variant associated with serious mental illness

2017-09-22

Abstract excerpt

<h4>SUMMARY</h4> Biological characterization of genetic variants identified in genome-wide association studies (GWAS) remains a substantial challenge. Here we used human induced pluripotent stem cells (hiPSC) and their neural derivatives to characterize common variants on chromosome 3p22 that have been associated by GWAS with major mental illnesses. HiPSC-derived neural progenitor cells carrying the risk allele o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a1e7d4df-d1cc-507b-815d-7d4b6b18acf2
DOI
10.1101/192815
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Sodium valproate rescues expression of <i>TRANK1</i> in iPSC-derived neural cells that carry a genetic variant associated with serious mental illnessDOI 10.1101/192815
Sodium valproate rescues expression of TRANK1 in iPSC-derived neural cells that carry a genetic variant associated with serious mental illness.Semantic proximity
Molecular correlates of topiramate and <i>GRIK1</i> rs2832407 genotype in pluripotent stem cell-derived neural culturesSemantic proximity
Modeling common and rare genetic risk factors of neuropsychiatric disorders in human induced pluripotent stem cells.Semantic proximity
The <i>16p11.2</i> microdeletion enhances gene expression variability between human IPSC derived forebrain interneuron progenitor cells in cultureSemantic proximity
Publicly available hiPSC lines with extreme polygenic risk scores for modeling schizophreniaSemantic proximity
Transcription factor binding and individual genetic risk for valproate teratogenicitySemantic proximity
Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.Semantic proximity
An Alzheimer’s disease-associated common regulatory variant in a PTK2B intron alters microglial functionSemantic proximity
Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric Disorders.Semantic proximity
Human-Induced Pluripotent Stem Cell Technology: Toward the Future of Personalized PsychiatrySemantic proximity
Alcohol Use Disorder Associated Gene <i>FNDC4</i> Alters Glutamatergic and GABAergic NeurogenesisSemantic proximity
Epigenome and transcriptome changes in <i>KMT2D</i> -related Kabuki syndrome Type 1 iPSCs, neuronal progenitors and cortical neuronsSemantic proximity
Select a neighboring publication to make it the new centre.