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Article

Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric Disorders.

Cell stem cell - 3 Sept 2015

Hyman Steven E

Abstract excerpt

Connecting rare genetic variants to neuropsychiatric disease mechanisms remains a significant challenge. In this issue of Cell Stem Cell, Pak et al. (2015) combine gene targeting and stem cell technologies to identify a significant cellular effect of rare penetrant NRXN1 mutations in human neurons, which was found to cause a defect in neurotransmitter release.

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Topics

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Share to Cell Adhesion Molecules, Neuronal
Share to NRXN1 gene
Share to Mental Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26340523
DOI: 10.1016/j.stem.2015.08.013

Genes

NRXN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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