Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sodium valproate rescues expression of TRANK1 in iPSC-derived neural cells that carry a genetic variant associated with serious mental illness.

Molecular psychiatry - 1 Apr 2019

Jiang Xueying, Detera-Wadleigh Sevilla D, Akula Nirmala, Mallon Barbara S, Hou Liping, Xiao Tiaojiang, Felsenfeld Gary, Gu Xinglong, McMahon Francis J

Abstract excerpt

Biological characterization of genetic variants identified in genome-wide association studies (GWAS) remains a substantial challenge. Here we used human-induced pluripotent stem cells (iPSC) and their neural derivatives to characterize common variants on chromosome 3p22 that have been associated by GWAS with major mental illnesses. IPSC-derived neural progenitor cells carrying the risk allele of the single...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytokines

Share to Induced Pluripotent Stem Cells

Share to Neural Stem Cells

Share to Neurogenesis

Share to Neurons

Share to Valproic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 30135510
DOI: 10.1038/s41380-018-0207-1
PMCID: PMC6894932

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sodium valproate rescues expression of TRANK1 in iPSC-derived neural cells that carry a genetic variant associated with serious mental illness.PMID 30135510Read ↗

Sodium valproate rescues expression of <i>TRANK1</i> in iPSC-derived neural cells that carry a genetic variant associated with serious mental illnessSemantic proximity Read ↗

Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.Semantic proximity Read ↗

Transcription factor binding and individual genetic risk for valproate teratogenicitySemantic proximity Read ↗

Molecular correlates of topiramate and <i>GRIK1</i> rs2832407 genotype in pluripotent stem cell-derived neural culturesSemantic proximity Read ↗

Transcription Factor Binding and Individual Genetic Risk of Valproate Teratogenicity.Semantic proximity Read ↗

Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric Disorders.Semantic proximity Read ↗

Molecular Correlates of Topiramate and GRIK1 rs2832407 Genotype in Pluripotent Stem Cell-Derived Neural Cultures.Semantic proximity Read ↗

Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced TeratogenicitySemantic proximity Read ↗

Haplotype-specific MAPK3 expression in 16p11.2 deletion contributes to variable neurodevelopment.Semantic proximity Read ↗

SORT1 Mutation Resulting in Sortilin Deficiency and p75(NTR) Upregulation in a Family With Essential Tremor.Semantic proximity Read ↗

Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.Semantic proximity Read ↗

Transcriptional profiling of fibroblasts from patients with mutations in MCT8 and comparative analysis with the human brain transcriptome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.